5-Amino-1MQ

Buy 5-Amino-1MQ — NNMT Inhibitor Research Compound

Researchers looking to buy 5-Amino-1MQ for laboratory study will find this synthetic small-molecule compound is the most extensively studied NNMT inhibitor research tool currently available. 5-Amino-1MQ (5-amino-1-methylquinolinium) is an inhibitor of nicotinamide N-methyltransferase, an enzyme that catalyzes the methylation of nicotinamide using S-adenosyl methionine (SAM) as a methyl donor. NNMT is increasingly recognized in research literature as a regulator of cellular methylation balance, NAD+ metabolism, and adipose tissue metabolic function.

Mechanism of Action

5-Amino-1MQ has been investigated in published research for activity across several biological pathways, including:

• NNMT enzyme inhibition — direct competitive inhibition of nicotinamide N-methyltransferase, the enzyme responsible for the methylation of nicotinamide to 1-methylnicotinamide (1-MNA)
• Cellular methylation balance — research on the influence of NNMT inhibition on the methyl donor pool, particularly S-adenosyl methionine (SAM) and S-adenosyl homocysteine (SAH) ratios
• NAD+ salvage pathway research — investigations into how NNMT inhibition affects nicotinamide availability for NAD+ resynthesis via the salvage pathway
• Adipose tissue research — preclinical research on NNMT expression in white adipose tissue and its relationship to adipocyte size, energy expenditure, and metabolic flexibility
• Sirtuin pathway research — investigations into downstream effects on sirtuin (SIRT1-7) activity through changes in cellular NAD+ availability
• Obesity and metabolic syndrome research models — studies on NNMT-mediated metabolic regulation in preclinical animal models
• Aging research — research on NNMT expression patterns in aging tissues and the effects of NNMT inhibition in cellular senescence models

5-Amino-1MQ is distinguished in research literature as a research tool for investigating NNMT-mediated regulation of cellular methylation and metabolic pathways. The compound’s mechanism — inhibition of nicotinamide methylation — represents a relatively novel approach to indirect modulation of NAD+ availability, complementing direct NAD+ precursor research approaches such as NMN and NR.

Research Applications

5-Amino-1MQ is widely used in research contexts including:

• NNMT enzyme inhibition and selectivity studies
• Cellular methylation and one-carbon metabolism research
• NAD+ salvage pathway and nicotinamide metabolism research
• Adipose tissue and adipocyte biology research models
• Metabolic syndrome and obesity research models
• Cellular senescence and aging research
• Comparative analysis alongside other metabolic research compounds such as MOTS-c, NAD+, and SLU-PP-332

Product Specifications

• Compound: 5-Amino-1MQ (5-amino-1-methylquinolinium)
• Form: Crystalline powder
• Purity: ≥98% (verified by HPLC and mass spectrometry)
• Available sizes: 10mg
• Third-party tested: Certificate of Analysis available on request

Reconstitution & Storage

5-Amino-1MQ should be stored at -20°C for long-term stability and protected from light and moisture. As a small-molecule research chemical, 5-Amino-1MQ has limited solubility in water and is typically dissolved in DMSO (dimethyl sulfoxide) or ethanol for laboratory research applications. Working solutions should be prepared according to the specific research protocol and stored at conditions appropriate to the solvent system used.

Researchers should consult published literature for recommended solubility parameters and handling procedures specific to their research model.

Shipping & Handling

All orders are shipped with appropriate packaging to preserve compound integrity. Domestic orders typically arrive within 2–4 business days. Tracking is provided on every order.

Important Disclaimer

This product is sold strictly for laboratory research and in-vitro use only. It is not intended for human or animal consumption, diagnostic use, therapeutic use, or any form of clinical application. By purchasing, you confirm that you are a qualified researcher or affiliated with a licensed research institution and that this product will be handled in accordance with all applicable laws and safety standards.

5-Amino-1MQ has not undergone human clinical trials and is not approved by the FDA for any use. Published research on this compound is limited to preclinical animal and cell-based models. This product is not a substitute for any prescribed medication.