MOTS-c

Buy MOTS-c — Mitochondrial-Derived Peptide Research Compound

Researchers looking to buy MOTS-c for laboratory study will find this synthetic 16-amino-acid peptide is one of the most extensively researched compounds in modern metabolic and longevity science literature. MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is encoded within a small open reading frame in the mitochondrial 12S rRNA gene, and was first identified in 2015. It belongs to a relatively new class of regulatory peptides known as mitochondrial-derived peptides (MDPs) — peptides encoded by mitochondrial DNA rather than nuclear DNA — representing a novel concept in cellular biology where mitochondria encode and release their own regulatory signaling peptides.

Mechanism of Action

MOTS-c has been investigated in published research for activity across several biological pathways, including:

• AMPK pathway activation — research on AMP-activated protein kinase signaling, a central regulator of cellular energy homeostasis
• Mitochondrial function — investigations into mitochondrial biogenesis, oxidative phosphorylation, and metabolic flexibility
• Glucose homeostasis — research on insulin sensitivity and glucose uptake in preclinical models
• Folate cycle and one-carbon metabolism — studies on MOTS-c’s interaction with folate-dependent metabolic pathways
• Nuclear translocation — research on MOTS-c’s documented movement from mitochondria to the cell nucleus under metabolic stress, where it influences gene expression
• Exercise-mimetic pathways — investigations into MOTS-c’s role in metabolic adaptations associated with physical activity in preclinical models

MOTS-c is unusual in research literature because it represents a newer concept in cellular biology — that mitochondria encode and release their own regulatory peptides that signal to the rest of the cell. This positions MOTS-c as both a research compound and a foundational tool for investigating the broader category of mitochondrial-derived signaling.

Research Applications

MOTS-c is widely used in research contexts including:

• Mitochondrial biology and bioenergetics studies
• AMPK signaling and cellular energy homeostasis research
• Metabolic syndrome and insulin sensitivity research models
• Glucose metabolism and adipose tissue research
• Longevity and cellular aging research
• Exercise physiology and metabolic adaptation research models
• Comparative studies alongside other mitochondrial-derived peptides such as Humanin and SHLPs

Product Specifications

• Compound: MOTS-c (Mitochondrial-Derived Peptide)
• Form: Lyophilized white powder
• Purity: ≥99% (verified by HPLC and mass spectrometry)
• Available sizes: 10mg/50mg
• Third-party tested: Certificate of Analysis available on request

Reconstitution & Storage

Lyophilized MOTS-c should be stored at -20°C for long-term stability and protected from light. Once reconstituted with bacteriostatic water, the solution should be refrigerated at 2–8°C and used within the timeframe indicated on the product COA. Avoid repeated freeze-thaw cycles, as they can degrade peptide integrity.

Shipping & Handling

All orders are shipped with temperature-controlled packaging to preserve peptide integrity. Domestic orders typically arrive within 2–4 business days. Tracking is provided on every order.

Important Disclaimer

This product is sold strictly for laboratory research and in-vitro use only. It is not intended for human or animal consumption, diagnostic use, therapeutic use, or any form of clinical application. By purchasing, you confirm that you are a qualified researcher or affiliated with a licensed research institution and that this product will be handled in accordance with all applicable laws and safety standards.

MOTS-c is not approved by the FDA for human use, and this product is not a substitute for any prescribed medication.